Group leader: Dr. Thomas Friedrich

•  Center for Energy Research, Budapest, Hungary (Balazs Madas)

•  Mayo Clinic Florida (Keith Furutani)

•  MIT Marburg / TUM Gießen (Klemens Zink)

•  PTC Prague, Czech Republic (Sarah Al Hamami)

•  HIT / DKFZ Heidelberg (Christian Karger, Oliver Jäkel)

•  Oncoray Dresden (Felix Horst)

•  Universität der Bundeswehr, München (Günther Dollinger / Judith Reindl)

•  Raysearch Ltd., Sweden (Industry Collaboration)

Access to the Particle Irradiation Data Ensemble

• Friedrich T, Pfuhl T, Scholz M. Spectral composition of secondary electrons based on the Kiefer–Straaten ion track structure model. Physics in Medicine and Biology 69:025013 (2024). doi:10.1088/1361-6560/ad1765

• Hufnagl A, Johansson G, Siegbahn A, Durante M, Friedrich T, Scholz M. Modeling secondary cancer risk ratios for proton versus carbon ion beam therapy: A comparative study based on the local effect model. Medical Physics 49:5589-5603 (2022). doi:10.1002/mp.15805

• Friedrich T, Pfuhl T, Scholz M. Update of the particle irradiation data ensemble (PIDE) for cell survival. Journal of Radiation Research 62:645-655 (2021). doi:10.1093/jrr/rrab034

• Friedrich T, Scholz M, Durante M. A Predictive Biophysical Model of the Combined Action of Radiation Therapy and Immunotherapy of Cancer. International Journal of Radiation Oncology*Biology*Physics 113:872-884 (2022). doi:10.1016/j.ijrobp.2022.03.030

• Herr L, Friedrich T, Durante M, Scholz M. A model of photon cell killing based on the spatio-temporal clustering of DNA damage in higher order chromatin structures. PLoS One. 2014;9(1):e83923. doi:10.1371/journal.pone.0083923

• Friedrich T, Ilicic K, Greubel C, et al. DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage. Scientific Reports 8:1-10 (2018). doi:10.1038/s41598-018-34323-9

• Grün R, Friedrich T, Traneus E, Scholz M. Is the dose-averaged LET a reliable predictor for the relative biological effectiveness? Medical Physics 46:1064-1074 (2019). doi:10.1002/mp.13347

• Stewart RD, Carlson DJ, Butkus MP, Hawkins R, Friedrich T, Scholz M. A comparison of mechanism-inspired models for particle relative biological effectiveness (RBE). Medical Physics 45:e925-e952 (2018). doi:10.1002/mp.13207

• Mirsch J, Tommasino F, Frohns A, et al. Direct measurement of the 3-dimensional DNA lesion distribution induced by energetic charged particles in a mouse model tissue. Proceedings of the National Academy of Sciences 112:12396-12401 (2015). doi:10.1073/pnas.1508702112

• Steinsträter O, Grün R, Scholz U, Friedrich T, Durante M, Scholz M. Mapping of RBE-Weighted Doses Between HIMAC– and LEM–Based Treatment Planning Systems for Carbon Ion Therapy. International Journal of Radiation Oncology*Biology*Physics 84:854-860 (2012). doi:10.1016/j.ijrobp.2012.01.038

• Friedrich T, Scholz U, Elsässer T, Durante M, Scholz M. Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern. International Journal of Radiation Biology 88:103-107 (2011). doi:10.3109/09553002.2011.611213

• Elsässer T, Weyrather WK, Friedrich T, et al. Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning. International Journal of Radiation Oncology*Biology*Physics 78:1177-1183 (2010). doi:10.1016/j.ijrobp.2010.05.014

• Scholz M, Kellerer AM, Kraft-Weyrather W, Kraft G. Computation of cell survival in heavy ion beams for therapy. The model and its approximation. Radiation and Environmental Biophysics 36:59-66 (1997). doi:10.1007/s004110050055