s > 3% the full sensitizing effect is observed, while at lower concentrations, especially from 1% to 0.1%, a steep decrease in radiosensitivity is measured (Oxygen Enhancement Ratio OER). High-LET radiation [...] highly conformal dose distribution of charged particles within a very short irradiation time (typ. 1-2 s; Fig. 1). Figure: a) Conformal dose distribution (12C, 400 MeV/u beam, sphere Ø= 5cm) produced by a 3D [...] (Basel). 2021; 11 (1):54. 4) Helm A, Tinganelli W , Fournier C, Simoniello P, Kurosawa F, Shimokawa T, Durante M. In Reply to Elmali et al.. Int J Radiat Oncol Biol Phys. 2021 Apr 1; 109 (5):1658-1659